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Kalman Hideg Selected Research

2- ((2- piperidin- 1- ylethyl)thio)quinazolin- 4(3H)- one

7/2014A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats.
1/2014PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.
7/2006PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.

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Kalman Hideg Research Topics

Disease

6Ischemia
06/2006 - 12/2002
3Neoplasms (Cancer)
12/2014 - 03/2008
3Heart Failure
01/2014 - 07/2006
3Infarction (Infarctions)
09/2006 - 12/2003
2Hypertension (High Blood Pressure)
07/2014 - 01/2014
2Hypertrophy
01/2014 - 07/2006
2Cardiomyopathies (Cardiomyopathy)
10/2011 - 01/2005
2Reperfusion Injury
09/2006 - 06/2006
2Myocardial Infarction
07/2006 - 06/2006
1Breast Neoplasms (Breast Cancer)
12/2014
1Glioblastoma (Glioblastoma Multiforme)
12/2014
1Lung Neoplasms (Lung Cancer)
12/2014
1Vascular Remodeling
07/2014
1Inflammation (Inflammations)
07/2014
1Squamous Cell Carcinoma of Head and Neck
01/2014
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2014
1Adenocarcinoma
03/2008
1Colonic Neoplasms (Colon Cancer)
03/2008
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
03/2008
1Ovarian Neoplasms (Ovarian Cancer)
09/2007
1Wounds and Injuries (Trauma)
09/2006
1Fibrosis (Cirrhosis)
07/2006
1Cardiomegaly (Heart Hypertrophy)
07/2006
1Ventricular Remodeling
07/2006
1Chest Pain (Chest Pains)
06/2006
1Angina Pectoris
06/2006
1Myocardial Ischemia (Ischemic Heart Diseases)
06/2006
1Cardiotoxicity
01/2005
1Vascular Diseases (Vascular Disease)
01/2004

Drug/Important Bio-Agent (IBA)

7Poly(ADP-ribose) Polymerase InhibitorsIBA
12/2014 - 01/2004
6Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2014 - 03/2004
4Pharmaceutical PreparationsIBA
07/2014 - 06/2006
4AntioxidantsIBA
01/2014 - 11/2003
4Proteins (Proteins, Gene)FDA Link
09/2006 - 12/2002
3Phosphotransferases (Kinase)IBA
12/2014 - 10/2011
32- ((2- piperidin- 1- ylethyl)thio)quinazolin- 4(3H)- oneIBA
07/2014 - 07/2006
3EnzymesIBA
01/2014 - 07/2006
3Reactive Oxygen Species (Oxygen Radicals)IBA
10/2011 - 01/2004
3NAD (NADH)IBA
02/2006 - 12/2002
2Mitogen-Activated Protein KinasesIBA
12/2014 - 07/2006
2p38 Mitogen-Activated Protein KinasesIBA
12/2014 - 06/2006
2Caspase 3 (Caspase-3)IBA
01/2014 - 03/2008
2Cisplatin (Platino)FDA LinkGeneric
01/2014 - 09/2007
2CurcuminIBA
01/2014 - 03/2008
2Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2014 - 10/2011
2Doxorubicin (Adriamycin)FDA LinkGeneric
10/2011 - 01/2005
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
03/2008 - 06/2006
2Glycogen Synthase Kinase 3 betaIBA
07/2006 - 02/2006
2WortmanninIBA
02/2006 - 12/2003
1Radiation-Sensitizing AgentsIBA
12/2014
1HO 3089IBA
12/2014
1QuinazolinesIBA
07/2014
1Transcription Factors (Transcription Factor)IBA
07/2014
1NF-kappa B (NF-kB)IBA
07/2014
1Protein Isoforms (Isoforms)IBA
01/2014
1Annexin A5IBA
01/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2014
1Angiogenesis InhibitorsIBA
01/2014
1CaspasesIBA
03/2008
1Antineoplastic Agents (Antineoplastics)IBA
03/2008
1Hexosaminidases (Hexosaminidase)IBA
03/2008
1diphenyl (biphenyl)IBA
03/2008
1Therapeutic UsesIBA
03/2008
1CalciumIBA
09/2006
1HO-3538IBA
09/2006
1Glycogen Synthase (Synthase I)IBA
07/2006
1Protein Kinase CIBA
07/2006
1CollagenIBA
07/2006
1Isoproterenol (Isoprenaline)FDA LinkGeneric
07/2006
1Protein Kinase C-epsilonIBA
07/2006
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
06/2006
1Creatine Kinase (Creatine Phosphokinase)IBA
06/2006
1Trimetazidine (Vastarel)IBA
06/2006
1Krebs-Henseleit solutionIBA
06/2006
1pyrrolineIBA
06/2006
1PeroxidesIBA
02/2006
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
02/2006
12- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
02/2006
1Adenosine Triphosphate (ATP)IBA
02/2006
1Phosphocreatine (Neoton)IBA
02/2006
1Free RadicalsIBA
01/2005
1AdenineFDA LinkGeneric
03/2004
1Adenosine Diphosphate (ADP)IBA
03/2004
1Purinergic P2 Receptors (ADP Receptor)IBA
03/2004
1HO3073IBA
12/2003
1Mexiletine (Mexitil)FDA LinkGeneric
11/2003
1thiobarbituric acidIBA
12/2002
16- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA
12/2002
1Phosphates (Orthophosphate)IBA
12/2002
1Thiobarbituric Acid Reactive SubstancesIBA
12/2002
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
12/2002

Therapy/Procedure

1Drug Therapy (Chemotherapy)
01/2014